Support Brain Health, Memory & Sleep with Nobiletin
Nobiletin is a polymethoxylated flavone found predominantly in citrus peels. It crosses the blood-brain barrier to deliver potent antioxidant, anti-inflammatory, and circadian-supporting benefits. Research highlights its ability to enhance memory, mood stability, and sleep-wake regulation, making it a versatile nootropic for daily cognitive and metabolic support.
What is Nobiletin?
Nobiletin is a polymethoxylated flavone abundant in citrus peels, particularly in tangerines and oranges. Unlike many flavonoids, it crosses the blood-brain barrier to exert neuroprotective, anti-inflammatory, and circadian-regulating effects.
- Blood-Brain Barrier Permeable: Delivers direct effects on neural tissues.
- Anti-Inflammatory: Reduces cytokines and oxidative markers.
- Circadian Support: Activates BMAL1 and PER2 clock genes.
- Neuroplasticity: Promotes BDNF, CREB signaling, and synaptogenesis.
Core Nootropic Mechanisms
- Circadian Gene Activation: Upregulates BMAL1, PER2 to improve sleep-wake cycles.
- Anti-Inflammatory & Antioxidant: Scavenges free radicals and lowers neuroinflammation.
- Neurogenesis & Synaptic Plasticity: Increases BDNF/CREB pathways and supports new neuron growth.
- Dopamine Modulation: Balances dopamine signaling for mood and motivation.
- CREB/BDNF Activation: Enhances learning and memory consolidation.
Core Benefits
- Memory & Learning: Strengthens long-term potentiation and retention.
- Mood & Resilience: Balances neurotransmitters, reducing irritability and stress.
- Sleep & Circadian Health: Synchronizes biological clock, improving sleep quality and daytime alertness.
- Neuroprotection: Shields against oxidative and amyloid-induced neuronal damage.
How It Feels
Users report a subtle, cumulative improvement:
- “I fall asleep more easily and wake up refreshed.”
- “Calm, focused energy without jitter.”
- “Sharper memory and less mental fatigue in the evening.”
Clinical Research Summary
- Circadian Restoration: Restores sleep-wake balance in clock gene-deficient mice.
- Alzheimer’s Models: Reduces β-amyloid accumulation and cognitive decline.
- Learning & Memory: Enhances CREB/BDNF signaling, improving retention in rodents.
Recommended Dosage & Usage
| Form | Suggested Dose |
|---|---|
| Standard Extract | 50–100 mg daily |
| Citrus Peel Extract | 500–1,000 mg daily (standardized to Nobiletin) |
Best taken in the morning to align with circadian rhythms and support daytime cognitive performance.
Ready to Enhance Memory & Sleep?
Side Effects & Safety
- Generally well-tolerated.
- Possible digestive upset or mild headache.
- Vivid dreams if taken too late.
- Avoid with MAOIs or sedatives without medical advice.
Caution: Consult a healthcare provider if pregnant, nursing, or on medication.
At a Glance
| Attribute | Details |
|---|---|
| Main Compound | Nobiletin |
| Mechanisms | Circadian regulation, BDNF/CREB, antioxidant |
| Benefits | Memory, mood, sleep, neuroprotection |
| Feels Like | Calm energy, better sleep, sharper recall |
| Dosage | 50–100 mg (pure) or 500–1,000 mg (extract) |
| Safety | Rare GI upset, headache, vivid dreams |